OK, here’s a few questions for you. Might help narrow down the problem.
Does the UI become laggy when you click on the track?
Do you have a lot of Plugins running? or have CPU heavy plugins running? (using linear phase or oversampling)
Are you using large sample libraries in the project at all? - if so, are the sample sets stored on a HD, SSD or NVME?
Are your projects running off a HD or SSD or NVME?
Does this happen when you click ANY track or just a specific track with plugins on? - might be a problem plugin causing it, either on the track or in the project.
What happens if you disable / remove all the plugins in the project? Do you still get the same issue?
Have you checked if there are updates available for your RME (firmware & driver)? Somewhere in the back of my head I recall RME and native UAD plugins were having issues for a brief period. These were fixed by a driver update shortly after if I am not mistaken.
OK so it doesn’t sound like GPU related. Although, if you have NVIDIA game drivers installed it can cause DSP latency that could cause issues. Ideally want to use Studio drivers for NVIDIA.
If you’re using a lot of libraries, dropouts could be caused if available System RAM is low, or if your drives were slow - but being SSD and NVME that shouldn’t be a problem. As for RAM, it’s a good idea to use purge functions to update sample pools for VST instrument patches, this will massively reduce the memory footprint.
It could be CPU hitting its limits if you have a lot of processing going on in the project or VST synths. Usually just disabling plugins one-by-one until it stops happening would be a telling sign. Which is easy to check.
If its being caused by a plugin - you can check by using global bypass in the mixer and see if the same behaviour still occurs, or use Constrain Time Delay button in the project toolbar. If it still happens, it’ll be case of saving the project as a new version, and removing all the plugins - purely to test if this makes a difference. If so, it’ll be a case of trying to find the offending plugin.