As you are/have invested in a pro audio production software, sound blasters and other low end consumer devices need to be give a wide berth. You might get lucky but better you invest in a product for the job by a branded, well known audio interface company. They are likely to have properly coded drivers for low latency audio IO for a start.
I use slotted cards as I have had good experience with them for decades. However they are actually becoming increasingly rare at the budget end for a home musician. You do not have a huge number of budget options available and I suspect that this will increasingly become the case. The best 2 in / 2 out is probably the RME HDSP etc, then you have a company called Marian and ESI. Also consider PCI and whether your motherboard or future motherboard will have such a slot. (Usually you need to be careful choosing a motherboard for PC these days as the vast majority do not have a PCI slot present, only PCI-E)
I think it is a case of researching and finding out other peoples experiences when it comes to the USB2.0/3.0 side of things, it may be the case that results become a little more system specific with USB relative to what devices you have attached to the system (using USB hub bandwidth). I for example have an Access Virus under TI USB control and I would not wish to upset that as it seems to be working well at the moment. Again, having loads of dongles, hard drives, and other devices set up could interfere with the reliability of audio data streams in and out.
Do as much research as possible before hand.