Audio System- Device failed to open


I am a total new user to Cubase, and I have been spending all my time trying to fix this issue, but I have no idea what I should do.

Window 10 64 biy
Cubase 12 Pro
Yamaha s90 es

When I click on studio setup, it says device failed to open.

Can anyone help me with this issue?

By the way, all the softwares have been downloaded and installed.


I would try to install the Audio Device driver as administrator.

What does the “Scroll Lock Off” mean? Where does it come from? This is not Cubase message. Is your system in a good shape?


I tried installing the audio device driver as administator but it is the same.
When I first open cubase, this shows up:

and when I click on studio setup, it shows:

I have Motu2 and Yamaha e90es connected to my laptop (but nothing between MOtu and Yamaha)

I installed the latest drivers for both, and I am not sure what is wrong.
Could you please help? I spent more than a week trying to figure this out…so sad


I would try to reinstall Cubase as administrator.

Hi Everything was working fine until the second time I opened Cubase 12.
All of a sudden, I could not hear the keyboard sound connected to my laptop.
However, everything else works fine.
It seems like Cubase does recognize the keyboard becuase everytime I play the keyboard, the sound bard goes up, but I cannot hear anything.
Could you please help???


In any case, I would switch the Out 1 and Out 2 from the screenshot. If you keep it like this, your L a R channels will be probably swapped in the speakers.

Do you have any Monitor Audio track created?

Should I try to reinstall audio interface and Cubase? Will that help? still cannot hear the sound of the keyboard while I can hear a sample track.
I am not sure what you mean by monitor track, but I dont have anything since I am just a starter.
Could you please help?