Well No body wants a noisy PC with many Drives , i cant verify , but i think , a separate drive 4 Vsti/s , ( dont know if the content should remain separate , many Vsti/s r just a Dll file , might as well put them 2gether ) , n i Didnt mean SSD yet , but Imagine the read n write head , spinning fast , reading / Writing Files on different platters , n bits u might need 2 use , makes the single drive very hot sure , as well , as will definitely reduce the life of the H/ Drive , even a P4 worked with 3 drives pretty well 4 me , i m going the SSD way soon , but only 4 the OS , another Point would b , i wouldnt trust the OS drive , its like a desk top , any thing can go wrong , OS files can get corrupted , Viruses , My important Data ( presets etc ) would b , probably safer on another drive , in case , the OS fails , i just reinstall , n of course , all the reinstalls of the Vst/is etc… just my opinion , i could b wrong sm