If you follow my steps, mentioned above to reproduce the issue, you should see the following.
Steps for first short Key
• Make sure Mixer Window is closed
• Press ALT+T (or your own short key) = Key Command: “Bypass: Insert on Main Mix”
• Now open the Mixer window you should see the following.
• Now press ALT+T (or your short Key) again
• Close the Mixer.
• Repeat all steps above only this time start with the Mixer Open the Result you should see is the same as before only this time you can see the yellow light turn on and off.
Steps for second short Key
• Make sure Mixer Window is closed
• Press ALT+Q (or your own short key) = Key Command: “Bypass: Insert”
• Now open the Mixer window you should see the following.
As you can see this time none of the Inserts where bypassed.
• Now repeat all steps for the second Key and this time start with the Mixer Open. You should see the following.
• Both Key commands are from the same category (Mixer)
• Both key commands perform a similar Task (bypass insert)
• Yet the first one does not need the Mixer Window to be in focus in order to perform its task.
Hope this clarifies things a little.