Combining a Steinberg UR242 with another interface in Cubase

Does anybody know if it is possible to use a UR242 interface in combo with another interface? I am currently using a Line6 interface with Cubase, withc is giving the guitar and bass sound i want. But on vocals and acoustic guitar i am thinking about getting a UR242. But do i have to switch between the input settings in Cubase between those two interfaces?

For best performance it’s probably better to switch.
However, Cubase isn’t limited to 1 device, it’s limited to 1 ASIO driver. If you can find a driver that works well for both interfaces you can use them simultaneously. If you’re on Windows, your best bet is ASIO4all. On Mac you can use aggregate device.