Cubase 10.0.50 inserts off in certain projects

Cubase 10.0.50 some insert plugins (include native cubase compressor) are turned off instantly. It’s impossible to move them, open any window of them, turn them on and even delete them. If I put some other plugin that works, I can move it on the “turned off insert plugin”, they switch their places and only after that I can click on “change plugin” and select “no plugin” for that slot. If I try to click on something else (like “turn on” or “open plugin’s window”) I would not be able to delete this insert anymore in that way I said! Cubase, drivers, plugins are was being reinstalled, other projects are work fine (even that particular Steinber Compressor). I deleted that inserts, rebooted the system, loaded that project but when I used to load some of plugins that I used there before - they are loading as “turned off” in the manner I desribed before. I have no idea what to do? Start a new project from scratch or is there something I can fix and continue my job?
Cubase 10 Pro, Windows 10 Pro, Apogee One. Everything is up to date.