I have crackles and I even re installed Cubase 10 elements + update. I have the latest driver from Focusrite.
My Desktop has Windows 10 recently re-installed and AMD FX 6300 6 cores processors 3.5 Ghz clock and 16 GB of RAM. I still have issues even a 512 samples I have crackles
All my software is legit , I am also using standalone Amplitube 4 and Overloud THU without any issue with my Focusrite Scarlet 2i2 2nd Gen USB interface.