Not used versions of Cubase 9-9.5. Tried to return to Cubase 10 Pro. I observe, like many here, the problem with random jumps of RealTime Peak, which after 40-50% of ASIO Average loads give clicks and spikes. The system is fully optimized, the latest drivers for all equipment are installed. The situation is slightly improved by disabling hyper-threading support in the BIOS. But does not solve the problem as a whole.
My system: Windows 10x64 Pro v1809, MB ASUS P8Z77-V, Intel Core i7 3770K 3.5Ghz, 16Gb RAM, ASUS Dual-GTX1060, Cubase Pro 10, RME Babyface, AKAI MPK261
I would not like to give similar examples, but I do not observe a similar problem in other DAWs. I also use the latest versions of Studio One 4, Reaper, Reason 10, Cakewalk BandLab. Therefore, I can say with confidence that the matter is in Cubase. In terms of performance and optimization, unfortunately at the moment it is inferior to them all. I look forward to future updates and solutions to these problems. Otherwise, figuratively speaking, why do you need a Ferrari, if it does not go! Good and good luck to the development team, I know that it is not easy for you now.