I have a similar setup… it’s just a little older but with a little bit more RAM. Since you have HyperThreading disabled and a similar setup, I have a question.
When I had HyperThreading disabled, I had an unexpected side effect… the current project had no audio anymore. There is nothing reaching the Standard-Out. New projects worked as expected but the old ones don’t. As soon as HT was enabled again everything worked as expected. This audio issue is on my system reproducible and is only related to HT.
Did you (or somebody else) encounter a similar behavior when HT get’s deactivated?
As soon as I am done with this project I will also deactivate HT since the Cubase performance boost is just unbelievable!
I hope that Steinberg keeps working on the workload topic. I like working with this DAW, but the fact that Cubase 10.0.10 introduced a fix so that only 28 real time threads (14 cores) get used, is hopefully just a workaround. The ASIO-Guard is in my opinion as well a workaround related to hardware. The above mentioned performance-boost could be related to the workload preparation that is not ideal. My above mentioned Cubase 10.0.15 behavior points out that low-level workload information get stored in the project and in summary I have the impression that the Cubase workload management suffers from a legacy software architecture.
Regarding this topic I am currently not happy with Cubase, because my hardware is not fully supported,… but the good news is… there is room for improvement!