Cubase 10 won't play Instrument files and won't record audio

I am very happy with Cubase 8, but forced to upgrade as Mac now upgraded to Big Sur OS. Trying to use Cubase 10, and much seems familiar from Cubase 8, but audio tracks will not record, and Instrument tracks seem to record (the tracks show data) but won’t play back.

I use Focusrite Scarlett interface, and it records to Cubase 8 fine but not to Cubase 10. I have verified in Studio all the audio connections and the Scarlett driver. Any help will be appreciated!