Cubase 11 and 12 Pro and Hardware

This relates to Cubase 12 Pro and 11 Pro

Does anyone have system with a similar spec to the one below who is using Cubase 12/11 Pro?

Motherboard: Asus Prime Z390-A
CPU: Intel i9-9900K
Graphics: Gigabyte GTX 1050 Ti WindForce X2 OC (GV-N105TWF2OC-4GD)
RAM: 64GB
o/s drive: Samsung Pro nVME
Other drives: Samsung SSDs (EVO/PRO)
Audio Interface: Apollo Twin Mk2 Quad Thunderbolt
o/s: Windows 10 Pro 64-bit 21H2

I would like to know if anyone with this spec or similar has any issues using Cubase 11 or 12?

Regarding W10 21H2, do you have Hardware Accelerated GPU Scheduling on or off? This can be off by default - but is this better on or off for Cubase 11 and/or Cubase 12?

And, as per this link: https://helpcenter.steinberg.de/hc/en-us/articles/360008589880-Windows-How-to-set-up-and-optimize-a-Digital-Audio-Workstation and this part:

Motherboard

We have had reports on poor performance on even high-end systems like an Intel Core i9.
It turned out that the motherboard and a specific UEFI BIOS version had issues with memory performance and the manufacturer suggested rolling back to an older BIOS version, which resolved the issue. As mentioned earlier on, BIOS updates are important but in rare cases, it is worth taking a closer look at the version history or even online discussions in the communities.

Which BIOS version do you use?