Thanks for that. Yes, Cubase works fine, it outputs sound to the UR242 without problem.
The problem is that the rest of my Windows system - i.e. any other programs, apps or system sounds - will then have no sound until I reboot.
I.E. There will be no sound from VLC player, Spotify, YouTube, etc (YouTube will no longer even play videos, it just has a spinning wheel and a message that I should restart my system if playback doesn’t work).
Worse; even after I shut down Cubase, my Windows system won’t play any sound, until I restart.
Once I restart, my system will have sound and work fine (e.g. I can play YouTube videos), until I start Cubase. Then I’ll only have sound in Cubase until I reboot my system.