FWIW, I was getting terrible, random freezes for one of my more intensive projects in Cubase 12. I could not track down the source. All plugins were up to date.
Out of desperation, I installed Cubase 10.5 to see if the issue would go away, and it did! But then I noticed that 10.5 defaults to HIDPI mode checked off. Turning it off in 12 stopped the freezes.
I’ve gone a couple days now without a freeze, so just putting this out there in case anyone else wants to try it. I’m running Windows 11, with an AMD 6600xt GPU.