It would help greatly if you could give us more information about your system.
Some questions come to mind.
Have you updated your graphics card drivers?
Have you updated your soundcard drivers?
Does this happen with every project?
Have you tried creating a new project to see if you are carrying something over from past projects?
Do you use 32 bit plugins? I am assuming that you are running Cubase in 64 bit.
I don’t know how to update my graphics card drivers.
I have downloaded and installed the latest Windows 10 drivers drivers for the Roland Studio Captures.
This happens on all my projects and only when using the Roland Studio Captures, which I have to use.
I do run Cubase in 64 bit and the only plugins I use are NI Kontakt 5 running the Rickenbacker Bass plugin.
This never happened until I installed Windows 10 about 10 days ago.
If you upgraded to W10 rather than clean installing then it would definitely be worth fully uninstalling Cubase…delete any left over folders and reinstall it clean for the new o/s.
What driver are you using? You say that you’re using a pair of interfaces, but ASIO can only communicate with one interface at a time except for special circumstances.
The Roland driver treats the two devices as one.
You can’t mix any old interface but with with multiple instances of the same device this is a fairly common option.