Cubase Ai4 & Yamaha 166c USB ISSUES

I bought the yamaha 166c usb a while ago, the reason was the possibility of live recordings with the Cubase Ai4. Technically everything is working fine, I got the mixer and the software working as it should. My problem is that every time I record there is a kind of interference noise which I tried everything to get rid off but is still there.
What could be the problem? Is that a software or is that a hardware problem?

Computer specs?

It potentially is an AISO buffer size problem, try increasing the buffer size.