Cubase Artist 6 and PreSonus Audiobox problems

Hi…I am using Cubase artist 6. I used to be able to record vocals using presonus audiobox but it is not working anymore. I am unable to both hear and record through my audiobox. Headphones and microphones do not work in cubase. I can not get any sound. I have done device set up and VST connection set up…output stereo(1) and input mono(2)…can anyone please help me? I really appreciate it. Love Inger