Cubase loses output sound, after restart returns

Hi all,

Just purchased my First Cubase license - have played around with trial before though, but am still a newb.
I am having a strange issue, actually two (not sure if related)

My setup: Cubase Elements 10 and M-Audio Code49

First issue: Output sound to headphone diasppears after using Cubase for a while. In Cubase everything seems to be ok, levels are showing that music is playing but nos sound to my headphones.
Second issue: I am getting interference to headphones from time to time.

Any suggestion what I could try to fix this issue?

Turns out it was Cyrus Audiokey that was causing both the issues, sorry.