Cubase Nutted up - lost panning, sound, solo a channel

Cubase 8.0.35, Mac OSX, El Capitan.

I did the patch to 8.0.35 and it’s been working great ever since. However, suddenly last night, I lost sound and lost panning on several channels. I was able to get sound back, then somehow got panning back.

Now suddenly this morning, I can’t solo one of my channels. I can mute the rest and it’s certainly producing output.

Anyone know what this is? And why does Cubase spontaneously combust? If I were a professional doing this for a living, I would be very concerned about loss in workflow.