So I finally found this thread, after having searched the forum before, but with the wrong terms obviously. I have opened another thread some weeks ago because I faced the same issue with the combination of AMD Ryzen (7950X), RME-Interface (UCX) and Cubase not initializing the ASIO driver seemingly randomly (until doing a reset of the driver in Studio setup). I didn’t know that the buffer size might be involved, too, I have mine at 128 samples.
In the end, I found out that the issue was actually related to the USB port which my UCX was connected to. After doing endless tests with Cubases’ setting, recreating audio connections etc, connecting the UCX to another port seems to have solved the problem. I actually have identified two other ports which work fine (as far as I can remember after so many tests…), one which randomly, but rather reliably makes Cubase stay silent.
In my case it was a port on a “AMD USB 3.20 eXtensible-Hostcontroller”. This was a Hub that had also a mouse, camera and keyboard connected, usually I check that the audio interface is alone on a hub, but it must have slipped one time… not sure if it is relevant.
The port that worked was on a ““AMD USB 3.10 eXtensible-Hostcontroller”, no other devices connected.