Cubase se3 and 64bit

Is there a performance benefit to installing Cubase into the Programs folder rather than the Programs (x86) folder?
I understand that 32 emulation is conducted when programs are installed into the (x86) folder.

My problem has been trying to install plug-ins into the 64bit setup.

Everything runs fine if I install Cubase into the (x86) folder but I figured perhaps there’s a performance benefit if it’s installed into the Programs folder (64bit), but I’ve had 0 luck getting VST plug-ins to work.

Any advice would be appreciated.