Dropouts with Presonus Studio Live series 3 mixer


I was just wondering if anyone else has issues, if using a Presonus StudioLive series 3 mixer with up to latest Cubase 11 Pro. I have major audio dropouts and stops with my system. And yes, it’s only Cubase doing it. Studio One Pro and all my third party standalone stuff work perfectly. I have tried all sorts of buffer settings, I do not have any C wait states or any of that. PC is well and truly capable. Spec in sig.