e-licenser USB shortage

Is it possible to run Cubase without having the e-licenser plugged in all the time? I really need that USB port!

No, get a decent hub, would be my recommendation.

Laptop or desktop? Mac or PC? You might be able to mount the (newer, smaller) USB eLicenser internally.

And make sure it is powered.

Thanks folks x

Yes definitely a powered/Active one, when using a Passive Hub You risk starving the dongle for power, with all sorts of issues as the result.