It looks like something has messed up the COM or DCOM registration of part of eLicenser Control Center. I think DEP is a red herring - it is enabled on my system with no opt-out for the eLicenser software and everything works correctly.
It might help to uninstall “eLicenser Control” using Settings → Apps → Apps and Features on Windows 10 (or the Uninstall feature of the Control Panel on Windows 7), then install the latest version. However, do not blame me if such a step makes the situation worse - it is only a reasonable suggestion based on the symptoms and lack of an alternative way forwards.