Using Cubase 10, but have also tried w/ Cubase 9.5.
Using a RME Fireface UFX interface…
Now when I set up my VST Connections exactly as I have for years, I see activity when pressing a key but no sound.
So I create an Audio track that has the keyboard set for Input Routing and Stereo Out for Output. I have the Midi channel set so that both input/output is the synthesizer, but that’s as far as it goes, no longer to Stereo Out.