Failed to communicate to UR44. Please restart UR44 and dspMixFx

After the last update I can not acces the UR44 Tools anymore. Got this message: Failed to communicate to UR44. Please restart UR44 and dspMixFx. I have delete everything and started all over again but with no result. Because of this the hardware inputs on my mixer (C10.5) are gone.
How can I fix this?

iMac Mojave, Cubase 10.5. UR44