Frustrated. Ready to don't push. Exe anymore

I’ve always used Cubase. Years of Optimizations, exchange of POV WITH people that have more powerful computers. Users complaining about the same problems (not all eh). But I’m not enjoying anymore. I tried tons of tweaking… Tons… it’s a continuation of spikes even on empty projects. With various cards. Rme. uad. Other programs don’t generate crackles and noises. What a frustration. Steningerb what happen?