Are you running out of headroom on your main buss? Trimming down the pre-gain on just the main buss should help.
If it’s done on a completed mix then some individual tracks would need some tweaking of course but it’s a something arrived at a long time ago from the days of analogue tape and mixing. It was desirable to record a lot on the hot side to add saturation/coloration and help get rid of the noise floor but that’s not true in the digital domain.
Most vst’s, especially sample libraries as well as compression eq etc demonstrate widely differing output levels, Every time you add another track or process it’s going to multiply the buss output levels somewhat so setting the gain stage structure is quite important. It really helps to avoid the sort of problem encountered by the op as well as leaving enough headroom allowing lead lines, and vocals and harmonic dynamics to stand out naturally without being squashed to death with over compression on the master busses and output.
Of course every one works differently and will use different methology, having the luxury of saving multiple mixes allows for such experimentation but really, correct gain staging is essential for open, breathing mixes rich in dynamic content.