How to edit MIDI controller settings without closing session?

The more easily understandable and generally useful version name for Win 10 can be found in Windows > Settings > System > About where it says Version. OS build (the long number you showed) shows the exact smaller bug fix release in-between. While one can deduce the Version from the build, it’s an extra step for most people (including me) who don’t work at that level of detail on a daily basis. So you’ll end up getting more takers for your questions when you mention Version numbers.
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However, I suspect that something else (not Cubase) is hogging that midi port. Just the other day another forum user discovered that the software for his audio interface was the culprit.