In FL Studio there is a tool called the Patcher. It basically allows you to engineer instruments/sounds to your imaginations liking. It works like Abletons Effects Rack where you can layer effects on top of effects, modulating individual parameters from each effect/instrument. In other words, it is an environment within the FL Studio environment that allows for unlimited creativity in terms of designing instruments and sounds.
Here is a video demonstrating some of its features:
Does this sort of thing exist within Cubase without having to resample?