Immediate blacklisting of plugins

Does anyone have any idea how you can work seamlessly in Cubase with many plugins one day only to pull up the project the next day and find a major portion are now blacklisted and largely cannot be used again?
I’m working in Cubase 10 Mac and will be moving to 12 very soon and this is what I’m trying to find a workaround for . Many of these plugins have been part of my daily work for years and I cannot see any reason for this as nothing has changed. Same computer, same system, same C10, same plugins

I’ve read everything I can find on the subject, reinstalled C10, trashed prefs and blacklist xml’s, tried new installs of plugs, etc. but no progress. If anyone has any input, I would greatly appreciate it!

Thanks in advance for your reply