Latency is not an issue while mixing. But when playing/recording using guitar amp emulations and VI’s, it is.
I’ve been testing my real time jam template with Metric Halo ULN-8/2d and a Lynx Aurora(-n) 32 with TB2 on my Skylake Hackintosh.
This template contains of 1 x Pianoteq 6 piano VI, 1 x Superior Drummer 3 drum VI, and 3 mono analog inputs, 1 vocal with compressor/eq/reverb, 1 mono electric guitar with amp sim, and 1 mono bass guitar with bass amp sim.
I use this template for jamming with a band, getting ideas down. Low latency is appreciated/mandatory for a good session.
The ULN-8/2d and the Lynx Aurora(-n) will work with the very occasional breakup with a 64 sample buffer @ 88.2 kHz in Cubase or Logic. This gives better results than 32 samples/44.1 kHz, which is unusable with this template in any DAW I tried.
The roundtrip latency(AD to DA through DAW) is about 4 mS in this situation, which is not a problem for any of the musicians(some with headphones, some listening to speakers) I work with.
There’s an experimental Lynx driver that is usable on my system for even lower latency(about 3 mS)
Logic is a bit smoother with this template, but Cubase is OK too.
In Pro Tools HD 12, I can’t use this template without terrible distortion and/or errors unless I have a buffer of 256 samples(or higher).
If latency is tolerable really depends on the individual musician. Some are very sensitive to latency. other’s not so much. One of the drummers I work with is quite happy to work with a 512 sample buffer (a whopping 27 mS of latency), and his drumming is fine.