To extend on what Daniel has said, if there any plugins that want to support MIDI 2.0 then they will need to implement VST Note Expression in a VST3 plugin (because the tuning support is based on Note Expression). MPE is a ‘poor man’s’ Note Expression in that it fakes per-note control by assigning every note to a separate channel, so that it can be transmitted using MIDI 1.0.
See also Arne Scheffler and Janne Roeper - Support of MIDI2 and MIDI-CI in VST3 instruments - YouTube