Midi Out erratic messages to my hardware

Hi, for some unknown reason since a few months ago, every time i play a midi file on loop, cubase 10.5 and send to any of my external synths or hardware, after a few loops repeat, cubase starts to change either the program, the filter or any know in my synths, in a kind of erratic way, normally either changes the program patch or turn the filter down… it happens with any synth not with one in particular.

Anyone faced this problem? it’s driving me crazy…