Missing Plugins

Hi, I reset the route of my plugins in Cubase 8, I added again, I rescan the plugins and every plugin appears on the list. The problem is that when I add the plugins to the default library or another library, they appears like missing plugins. They also don´t appear on the list when I add an instrument track and my projects with this plugins don´t load them.
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I have my Cubase on spanish, I use the plugin Spire x64 as example that appears like a missing plugin.
Hope someone can help me, thanks.