You can’t get much simpler and easier for beginners than a 2 channel Steinberg audio interface with Steinberg Cubase software. It works great, and there is nothing very difficult about any of the software.
As far as learning, these days most people will find some amount of just trial and error and some youtube tutorials will get you started. The UR22 has a midi in and out port, so any midi capable keyboard, a UR22, and a pair of decent quality powered studio monitors (like the KRK ROKIT) or (if you prefer, a pair of studio quality high impedance headphones in the $200-$400 us range) will be all you need to make and mix your own music “in the box”, or to record some guitar and vocal parts.
You don’t even need to buy any VST plugins as there are some included, and there are plenty of free VSTs, such as DEXED if you want to create some FM Synthesized synth parts. Cubase (all editions, even AI) includes even a pretty good electronic drums system called GrooveAgent SE, and a basic sample playback vst called Halion Sonic SE that has a factory patch kit that has quite a lot of pretty good sounds in it.
In my view, you can ONLY learn this stuff, music production, and playing keyboards, and recording voices and guitars, by doing it. You just do it, and you hope you get away with it. (Matters of art are matters of taste. But matters of music and music production are both creative, and are also matters of discipline, craft, and skill, and you build those things by doing it, until you get better at it, the way a wood worker gets better by making things.)