Hello gentlemen,
I found this thread via google search for the same reason, bad working 2.1.1 driver for UR22mkII on my Win10Pro x64 system running on Dell E5570 causes sound drops and LED blinks. BUT IMPORTANT, just rollback didn’t enough for my issue, so I ran great tool named LatencyMon and it tolds me, that there is some CPU throttling HW feature (and WiFi device, of course:)), which is better to be turned off (because it’s just stealing rescources needed for running audiostream), so I uninstalled few vendor (Dell+Intel+Realtek) unneeded SW, drivers and Windows features, and also kicked off SearchIndexer (one of the really working tips for easier life
bcs this sh…y beloved “helper” is just picking the best moment to start its “very important” job, typically when system is almost fully loaded and working, because you need to get something done…so my one and only attempt is to kill it, ban it, delete it, disable it - everytime it appears, everywhere I saw it. and to disable entire Windows Search service for something like forever:)) at first. Then I disabled almost all start-up trash (waves+realtek audio services also), stopped and disabled lot of always running, but never used services (like Hyper-V, Xbox, Store, AR and VR, support, next HW vendors ballast, and upper noticed W. Search), then I restarted PC to BIOS and turned off HW virtualization, and finally, I disabled two most suspicious Intel features named “C-states control” and “TurboBoost”, well known to everyone:).
After boot to Windows again without any crash or something (and with dear UR turned off) I installed our mighty driver v2.0.4, switched it on and guess what, it works! The true is that I played some music just for few minutes, but without any drop od blink of LED, so I guess I got it.
So next time (if any, haha:)) you don’t have to reinstall and set up whole OS from scratch for issues like this, because Windows imho+afaik tends to be slower and bigger (and die in blue, sooner or later), if you leave it to do its job and hope for the best:D It’s always better to customize it (slightly or heavily, it’s up to you) properly for your own usecase, to maintenance system and storage time-to-time (monthly at least), to back all your important data like projects, your copies of purchased SW with licences, collected material and instruments, all related documentation and manuals and whatever you think you (will) need to, up to multiple places.
I’m trying to hold the rule of three: first copy is the one which I work on/with, second copy is mirrored (more or less online) to cloud storage, accesible from everywhere (so-called live copy), and third copy is updated time-to-time to 3,5" HDD, which I’m keeping in some safe space like drawer at home, out of the PC, offline, packed in antistatic bag at least (humidity and shock protection are good choice too) and updated time-to-time in pretty large batches with everything else (so-called dead copy). Another good decision is to make the backup clone of entire system to some ext. media in the moment, when you finished the new installation of OS and all SW with all registrations, settings, plugins, cusomizations etc., it’s always easier to return to this point, it’s just ready, and Windows can do this
And definitely, if any issue appears, to use proper tools (built-in-system too) and ways to get info, which helps you to find and choose right solution, then you can decide wisely, what is the effective way. Because simply, we don’t have time enough to reinstall Windows each year 
We have one nice rule here, says: “If it works, don’t fix it.” Sometimes I tend to forget it, then usually finding myself in the middle of battle with my own conviction about the smart myself 
P.S.:anw this wasn’t my 1st experience with this behavior. I had similar issues with similar setup before…