No sound in new projects

Hey guys,
could you help me please with my Cubase 5? Everything works fine in older projects, anyway when I want to create new project, there is no sound. When I open my old ones, there isn’t any problem. So tell me, where could be the problem.
I’d be very grateful for any advice which would help

ASIO selection?
Sound card routing?
VST Connections?
Preferences?

Audio?
MIDI?
Plugs?