No sound. Why...?

I´ve got a problem. I´ll try to describe it (the english language isn´t my best discipline…)

I installed Cubase AI and everything was alright for a couple of month. But all of a sudden I can´t listen to anyting else than the Cubase-files. Not Youtube, Spotify, MP3-files etcetra.

If I connect the loudspeaker-cable direct into the computer instead of qoing through Audiogram 3, I can listen to Youtube, Spotify, MP3-files etcetra (but not Cubase-files).

Does anyone understand what´s wrong?