Nuendo 12 / Komplete Kontrol S88: No sound

I’m back to Nuendo after few months (and some Nuendo updates) due to me working in other DAWs, just to disappointingly discover that no sounds is coming anymore out of Nuendo when using my NI Komplete Kontrol S88 MIDI controller (immediately tested with the latest version of Cubase 12 Pro and there it luckily still works!).
All other DAWS I regularly use the device with (Digital Performer 11, Studio One 6, Live 11, Bitwig 5 and FL Studio 21) work fine.
Any others experiencing similar issues?