Nuendo, Cubase, Reaper, Logic, in my experience this doesn’t matter in games. Nuendo has a Game Audio Connect feature but this is only useful (in my opinion) for bigger game studios working with a specific audio middleware for games called WWISE. Other than that Game Audio Connect doesn’t give you any advantage.
For games, you deliver raw WAV files. They are then loaded either into a middleware (WWISE, FMOD…) or directly imported into a game engine (Unreal, Unity 3D).
This means Nuendo is a choice you have to make. You need to decide if Nuendo saves you a lot of work and is worth the investment. To me it does. I have field recording sessions for game sound effects where I trim all recordings and create mutliple takes or variations of the same sound effect. Then I can just select all clips and export them in one operation. Nuendo routes each clip through the complete signal chain with compressor and limiters on the master channel intact, renders the file, names it after the channel and adds a number to it so I can have more than one file per track (which I use for variations, multiple takes). For a simulation game we recorded hours of vehicle effects and I can make a small change in my master channel’s limiter and export 1000 sounds in one go with proper naming. It’s really great. Reaper can do it too, but Reaper only routes audio through the current channel of the audio clip, meaning every channel has to have its own limiter for example. Good luck making one change to 100s of tracks.
Also in Nuendo, I can have multiple marker tracks. For more complex, designed multi-track sound effects, I create cycle markers and name them. Later, I can do the same and export all sections within cycle markers, mix them down to one sound file, and name it after the name of the cycle marker. It helps me save so much time, so for me it was worth it. And with the latest update to 8.2 it really feels snappy. Even the horizontal scrolling wheel works again
So this stuff is important to me in game sound. At the end of the day, I have to deliver WAVs. But I don’t work in a AAA facility in a team. Hope that helps.