Opening Cubase 4 drops audio interface


New problem for me. Bought Focusrite Scarlett 2i2, works fine on Mac (El Capitan 10.11.6). When I’m opening my Cubase 4, it drops the interface and starts using internal i/o. Trying to change it back, nothing changes. Any ideas?

Yes, there’s a signal at focusrite, totally scrambled and cliping, sound pref shows it has switched back to internal i/o.