OSX graphics?

It seems like there is display sync problems with cubase. Even more on 10.5 than 10.
I get really slow response with 4K@60Hz displayport 1.2. Anyone else that use that?
Cubase has very low framerate, little cpu usage and the is no problem to start up video in parallel.
The really odd thing is that MCU display also slows down. Any ideas?

I have found out that a remove of the RME TotalMixFX window improves the framerate a lot and the repressiveness of cubase 10.5.0 get on pair with 10.0.50.