I’ve got a UR44c on a 2018 mac mini via USB-C and the 2.0.5 driver on Catalina would crash the whole computer after a couple of days. Going back to 2.0.3 it was solid for months.
I recently updated it to Big Sur as Apple has been bothering me to for some months, 2.0.3 no longer works so with a sigh I installed 3.0.5 hoping it was actually stable given it’s been the latest release for some time.
No, it is not. My computer has crashed in the night after 2 days with the Yamaha USB driver front and centre in the crash log.
I’ve done a time machine backup, reinstall and restore of the whole computer, and it was stable before with 2.0.3 so I don’t think it’s the hardware.