Problem UR22 mkII disappear setup with Smaart v8

I have a problem with a one of my interfaces, exactly with Steinberg UR 22mkII, when i bought the interface I plug in the computer, I made the setup in Smaart v8 and works awesome, but when i unplugged and plug it again all my setup disappear & appear like a new interface! Everytime when I plugin my interface I have to make my setup again, Im running at OS X 10.11.6 and I’ve installed the last driver and firmware!

Is there any solution for that?

i have sam problem in studio one,unpluged interface plug it again and setup starts again what de hell??? Ur 22mk2 here is the photo of it,https://ibb.co/irpOSS

Pretty sure that’s not the same issue. Make sure you have the latest driver and firmware installed:

https://www.steinberg.net/en/support/downloads_hardware/yamaha_steinberg_usb_driver.html

https://www.steinberg.net/index.php?id=downloads_ur22mk2&L=1

im using fresh install of windows 10,after the win update that hapens ,al drivers and firmware up to date,laptop used acer e5-521 ,

I would recommend contacting Steinberg Support through your MySteinberg. They should be able to help you.