I had no problem with Cubase 5 and XP, but I cannot get it to work fully in Windows 7 64 bit. The Mackie though works with Samplitude 10 in Windows 7. It seems to be an Cubase issue. On XP, there was USB drivers to choose from. Now the USB driver is called MCPU Pro USB and midi n2 CMCUP10 USB.30 for my Mackie Expander.
I would appreciate if Steinberg would look further into this issue.