Restarting Computer/have to re-install drivers?

I have an iMac, 2.7 GHz Intel Core i5 with a 1T fusion drive. My interface is the UR22 and I have the latest Yamaha driver installed. Every time I restart my computer, I have to re-install the drivers! I’ve read through and followed the uninstall/install procedures a dozen times but it never works. I have a the OSX 10.9.2 all up to date. The funny thing is, I have the same OSX installed on a portable HD and when I boot to that, everything works great. I think there are still issues with the fusion drive. Anyone else have the same problems?