Running Nuendo 4 on Mac OS X Sierra or High Sierra

I am running Nuendo 4 on Mac OS X 9.4. Now I need to upgrade to OS X 10.11 or 10.12 (Sierra or High Sierra), and I wonder if I will have troubles running Nuendo 4 on those. Anyone has experience?

Not sure about 4 but I can tell you that 5.5.6 runs on Mojave with extremely poor graphic detail hence the reason I am using it on my PC only, Personally I doubt you will have a better experience with 4 and I would suggest you not to change your OS unless you are willing to compromise graphic details by quite bit.