I would say that it “should” work with no issues. On my old Windows 7 computer (which I still use periodically) the USB connections are actually coming from one connection on the motherboard. So effectively, what seems like separate USB ports is actually an internal USB hub. I never had any Cubase issues with that PC and latency issues were nil. So… as far as latency goes for you… who knows. You really would need to try it out on your system.
Like you said, definitely get a powered hub. They are not expensive and, going by your description, you don’t have enough USB ports. So you have to do it unless you purchase another computer. Good luck. 
Regards 