Set up separate input and output devices

I need to set a Line 6 Helix as the input source and an M-Audio 2x2 as the output source. The device setup only lets me set up one or the other. If I set the inputs of the 2x2 to off, and want to setup the Helix as the stereo in, I can’t.

Shouldn’t there be separate setups for in and out?

Only if they run from one ASIO driver. How this can be worked around for PC and Mac is posted plenty on the forums. for example only 3 posts underneath yours… :unamused:
https://www.steinberg.net/forums/viewtopic.php?f=181&t=56755&sid=e520af99b5d2b436b0372f2f76cc10c3